What is Trimix & How Does it Work?

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June-22, 2022

The inability to reach or sustain a normal erection capability of performing sexual intercourse is known as erectile dysfunction. This is a disorder majorly predominant among men between the age of 40 and 70. Statistics have shown that in the United States alone over 20 million men experience this disorder and are inevitably projected to increase drastically to over 300 million in the year 2025. The well-known standard treatment for ED is oral phosphodiesterase type 5 (PDE5) inhibitors like Sildenafil and Tadalafil; 

These act by preventing the breakdown of cyclic Guanosine-3', 5'- Monophosphate (cGMP), which causes the corpus cavernosum inside the penis to relax, resulting in penile erection. 

Some people actually may not be able to tolerate the PDE5 inhibitors for whatever reasons or do respond poorly to this type of treatment. There is therefore a tested and trusted ED medication alternative that individuals see as an option it’s called Trimix.

Trimix is a worthy alternative for men whose PDE5 inhibitors do not work. Another alternative Bimix Injection, Bimix is a different option that has been tested with promising results in the treatment of ED. Bimix is a second-line medicine used to treat ED in men who aren't candidates for PDE5 inhibitors. 

Components of Trimix 

The name trimix is derived from the combination of three compounded drugs which are phentolamine, papaverine, and alprostadil in different concentrations. This ED drug is not sold in any traditional retail pharmacy; it can only be made in compounding pharmacies. 

TriMix's components have been demonstrated to have a synergistic impact in creating prolonged penile erections in people with ED. TriMix injections for ED treatment is an injectable medication that is injected locally into the penis, as opposed to the first-line drug treatment for ED, PDE5 inhibitors, which are taken orally. This drug is often compounded at dosages that are specific to each person's needs. Below is further information on the components of TriMix injection. 


Phentolamine is in the class of alpha-adrenoceptor antagonists, which means it distorts the activities of epinephrine and norepinephrine on the alpha receptors in the human body. Norepinephrine and epinephrine will produce vasoconstriction of the arteries in the corpus cavernosum of the penis, which now leads to penile detumescence. The work of phentolamine is to block alpha receptors and prevent adrenaline and norepinephrine from bonding together with them and exerting their vasoconstrictive effects, this process aids penile erection. 

When phentolamine is administered by injection, to you it has a fast array of actions, which makes it last from 5 to 20 minutes, with its peak taking effect anywhere 10 minutes from when it is been administered. Its half-life of 30 minutes has a lasting effect anywhere from 1 to 4 hours. 


Alprostadil is another known medication that is produced to control the effects of ED, it is also called prostaglandin E1. Alprostadil is a powerful vasodilator that helps to widen the arteries of the corpus cavernosum. It also operates by smoothening the muscles of the corpus cavernosum and expands the caver Nosal arteries when you administer the injection into the penis, causing penile tumescence. Your body quickly digests it with the metabolism of over 80% of alprostadil after the first round of the body. Its brief half-life last approximately 5 to 10 minutes. 


This is an alkaloid in the human body that possesses vasodilatory and smooth muscle relaxing properties. It operates by blocking the metabolism of cyclic Adenine Monophosphate and cyclic Guanosine Monophosphate, similar to typical PDE5 inhibitors; it also inhibits voltage-gated calcium channels. The smooth muscles of the corpus cavernosum relax as a result of these mechanisms, allowing for greater blood flow to this location, which can help in penile erection. 

How to self-Administer 

Trimix is an injection that is administered into the penis. It can be self-administered locally, which allows you to administer your medication without having to meet with the doctor frequently. Trimix injections instructions for use include injecting yourself 3 – 4 times weekly, although there must be at least in between each usage 24 hours gap. It is a painless procedure if administered the right way. 

Other Trimix injection instructions for usage are as follows: 

- Maintain proper hygiene by washing your hands with an alcohol-based substance. 

- Clean the top of the rubber cover with an alcohol pad. 

- Without any air bubbles in the syringe insert the syringe and draw out the prescribed amount from the vial. 

- Locate the point to inject on the penis which are the sides of the penis, avoid the top or bottom of the penis, and avoid any obvious veins or repeated use of a particular spot. 

- Once you locate a site for injection wipe with an alcohol swab. 

- Insert the needle slowly and release the trimix injection into the penis. 

- Massage and rob the injected part gently after administering the injection. 

How Does It Work? 

As previously stated, TriMix injection is a synergistic compounded drug. The components of trimix could have the capability to form a penile erection. When these ingredients are combined into a single medicine, however, their favorable benefits can be amplified. The mixture of the three medications has a stronger effect than their effects in isolation. What trimix would do after administering the injection is to allow the rush of blood into the corpus cavernosum so the penile can expand and relax. This could lead to long-lasting penile erections that endure throughout the sexual encounter. 

Read More - Getting Trimix Injections in Florida (Sun City Center)

Who Needs Trimix 

TriMix is only advised in males who have signs and symptoms of ED as a compound medicine; although it’s separate components may have several therapeutic purposes. People having ED are not expected to make Trimix their first option. Before trying to adopt the use of intracavernosal injection therapy in the case of addressing ED, patients are enjoined to use the traditional therapeutic technique (PDE5 inhibitors). 

Reasons men having ED will make an attempt to use Trimix: 

- First-line medication, such as PDE5 inhibitors, does not provide sufficient outcomes. 

- PDE5 inhibitors cause hypersensitivity or other side effects in them. 

Injectable TriMix has been shown to be effective in the treatment of ED. According to studies, TriMix has had a success rate of 80 to 90%. 

How Safe is Trimix? 

TriMix is generally safe for most men to utilize. Since its inception more than two decades ago, this class of medications has undergone significant research and analysis. However, some men should be cautious about using TriMix injection as their primary ED treatment. The following men may be considered to be totally or somewhat contraindicated when using TriMix: 

- Men who have shown hypersensitivity to any of the TriMix ingredients. 

- Men who are taking blood thinners or other drugs that could impair blood coagulation. 

- Men who suffer from priapism (prolonged erections) or who have medical disorders that could lead to priapism. 

- Men with sickle cell anemia, or multiple myeloma, suffer a malformation in the architecture of their penis. 

- Infections or sores on the penis that haven't healed. 

There has been no definitive research on the dangers of taking TriMix with oral ED medicines. In general, taking oral ED medicines and TriMix within 18 to 24 hours of each other is not recommended to reduce the risk of serious adverse effects. Before using these two groups of drugs together, seek advice and recommendations from a health care provider. 

Benefits of Trimix  

TriMix injections have several advantages over other medications used in the treatment of ED, including the following: 

- The effects are immediate and long-lasting. 

- The administration is straightforward and painless. 

- TriMix has a high success rate, according to studies. 

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